Rhema Blog

Rhema Blog

Franco Cavaleri speaks to training recovery from experience as a former Mr. IFBB North America: Curcumin BDM30™ supports improved recovery rate

Ivan Leonov - Thursday, December 21, 2017

(Franco Cavaleri PhDc Mr IFBB North America 1992) Imagine being able to get into the gym to train a body part more frequently than your competition can. What does that mean to you in six months of steady training? Imagine recovering faster from a stage-to-stage or day-to-day workload in your competitive sport such as a cycling tour; a triathlon competition; or an all weekend cross-fit event. The advantage is possible with Curcumin BDM30™.

franco3 front-150x150 (Franco Cavaleri PhDc Mr IFBB North America 1992) Research demonstrates that myogenic potential and anabolic drive can be limited by mismanaged NF-kB. NF-kB is a transcription factor responsible for regulating as many as 150 genes that manage and beckon the immune system and inflammatory response. Anabolic drive and recovery of lean muscle is meticulously orchestrated by the cytokines that NF-kB manages, including TNFα. TNFα partakes in and advances inflammation that is necessary for recovery and restoration but can also be a limiting factor in your pursuit to maximum form.
The inflammatory process plays an important role in recovery and regeneration of tissue, including myogenesis (muscle generation). Skeletal muscle cells are said to be one of the most adaptable cells/tissue of the body. The underlying objective with resistance training, for example, is to evoke microtrauma of the working skeletal muscle cells resulting in cell signalling that activates satellite cells in the vicinity of the strained fiber. This activation prompts aggregation and fusing of these cells with mature muscle fibers. This is the compensatory hypertrophy we expect to occur as an adaptation feature to the extra-ordinary workload by the workout, adding muscle mass and strength over time.

That prolonged soreness that often persists to the next training day, however, is a problem. Prolonged survival of that post-workout soreness is indicative of longstanding TNFα and more generally, inflammation. If prolonged, inflammation can interfere with maximum recovery potential. This translates into interference with your personal potential.

franco1Front (Franco Cavaleri PhDc Mr IFBB North America 1992) Research shows TNFα inhibits myogenesis the mechanism of which is repression of MyoD protein. MyoD expression is central to cell restoration and differentiation – it’s essential to the generation of muscle tissue. Prolonged survival of the inflammatory process to inhibit MyoD protein interferes with recovery, immunity and myogenic (muscle building) potential. Downregulation of training-related and age-related inflammatory activity has both an anticatabolic influence and promotes anabolic drive to restore maximum muscle protein anabolism.

During my climb up the bodybuilding ladder I was fortunate enough to enjoy win after win from junior events all the way past national to international events – Mr. IFBB North America (1992). This includes the overall title of most shows in which I competed. Many things factor into such championship form including nutrition strategy; training tactics; genetic propensity; raw drive and determination; intuition to evolve strategies and more. Since every competitor is aiming every boon at their disposal at a championship outcome you need to apply everything you can muster. Every tool at your disposal must be put in play to contribute to the edge you may need to stretch past second place to first. In addition, there’s often very little separating first from third so everything counts; and every little factor counts that much more the higher you climb.

2 worlds collide How much my anti-inflammatory strategy contributed to the championship outcome for me is hard to quantify based on the fact that there are so many variables at play. My experience and my gut tell me it played a significant role. However, today our research is also uncovering mechanisms that may support the curcumin load scientifically. In fact, based on the subcellular activity induced by these curcuminoid fractions that our laboratory has been able to demystify; and that which is now also available in the literature I would not do things differently if I were to repeat the journey. There is much work to be done to further clarify this activity; nevertheless, what we now know is irrefutable. I take BDM30™ and BDM50™ abundantly today to stay in the zone and consistent with my training at 50 years of age.

Although curcumin can deliver an inhibitory effect on NF-kB transactivation and transcription of inflammatory cytokines, including TNFα, the new discoveries at Biologic Pharmamedical Research (www.biologic-med.com) showing MSK1 inhibition by BDMC (Curcumin III) changes the game. Curcumin BDM30™ is a result of these discoveries and it stops inflammation by inhibiting two proteins (NF-kB and MSK1) associated with the genesis of inflammation instead of one protein. Regular curcumin 95% typically only inhibits one (NF-kB) and does so mildly. Investing the time and effort into training to improve health and advance performance requires the best return possible. Imagine again being able to get into the gym to train a body part or work a training cycle more frequently than your competition can. Imagine again, maximising MyoD expression and anabolic drive. This time get with the program to make it happen with the patented Curcumin BDM30™ taken daily just before or after the workout. If you don’t, someone you know will likely beat you to it and may even do so to the first place podium.

Conflict of Interest Statement. The author/researcher is the owner of a biomedical research group – Biologic Nutrigenomics Health Research Corp and Biologic Pharmamedical Research, that funds and executes research on the pharmacology of nutritional and nutraceutical agents that are studied in the context of disease pathology including characteristics that have been associated with inflammation and dementias. The research on these findings continues at clinical levels to further investigate the full indication-specific potential of this discovery. The author/researcher is also the owner of related Intellectual Properties. author copyright Franco Cavaleri PhDc

Franco Cavaleri, BSc, PhDc, is The Rhema Group’s Chief Science Officer. He is also the principal research scientist at Biologic Pharmamedical; is a former Mr. IFBB North America; and is completing a doctoral degree in Experimental Medicine in the Faculty of Medicine.

Franco Cavaleri Speaks to: Curcumin BDM30 is the new household name based on research that changes everything we know about curcumin

Ivan Leonov - Monday, December 11, 2017

Look for products made with Curcumin BDM30™

Curcumin is quickly becoming a household name and noted to be one of the more potent anti-inflammatory agents among the natural therapies. We hear about its application in the treatment of Alzheimer’s, depression, colitis, Crohn’s, arthritis, injuries, hypertension, hypercholesterolemia and so much more. Despite its effectiveness for some people and some conditions, lack of reliability or consistent results is an ongoing problem even for long term users. So is this hit and miss miracle from nature supported by research?

One main reason curcumin can be applied with reasonable effect to treat many of these conditions is inflammation is a fundamental process or chemistry that is common to most if not every disease we face. This includes diseases like depression that appear to be far removed from our mainstream notion of inflammation. Most drugs we use to treat disease today are effective at neutralising this inflammatory activity in target tissues or cells. The different drugs target different proteins involved in this long pathway to immune system and inflammatory activity.

Typically, a unique disease is characterized by a mutation or regulatory anomaly of a unique protein involved in these inflammatory pathways. They work much like dominoes that keep the flow going in an intended direction. If one domino in the line is damaged or warped it could alter the pathway. In a very simple model like this each domino represents a regulatory protein in the long pathway; each ever-so-slightly- guiding the flow. A unique drug targeting this damaged protein, for instance, may inhibit the inflammatory process with precision for this disorder if it corrects completely or to a degree it counters the activity of this specific malfunctioning protein. Nevertheless, by targeting other proteins in the same pathway to slow down the flow, we can slow down inflammation sometimes additively.

Research shows curcumin to be a mildly effective inhibitor of a key protein called a transcription factor (namely NF-kB) involved in the escalation of inflammation. Other proteins are affected as well but we will keep this simple. Poorly regulated NF-kB escalates inflammation by literally transcribing, at the genetic level, cytokines such as TNFα and many others. If pushed out of control by a genetic mutation or damage of a naturally built-in regulatory loop the transcription (or production) stays ON too long without controls. Curcumin can be used to take the edge off many disorders because it slows down NF-kB but it can only do so if it is properly extracted to yield the right proportions of the subfraction curcuminoids.

Regular old curcumin (even curcumin 95%) is not reliable and is usually not potent enough to deal with deep rooted inflammation that is caused by damage to regulatory systems beyond NF-kB. (inflammation can be escalated by mutations leading to poor regulation of other key proteins in the same LONG pathway. These key proteins are often referred to as ‘drug targets’ by pharma researchers because they represent stop points in the expansive pathway where a drug could make a difference if it were able to modulate the protein.

The latest research discovery at Biologic Pharmamedical Research shows us that these underlying curcuminoid components in the curcumin extract have different drug target activity. They can target different regulatory proteins; some of which are in that inflammatory pathway. Treatment success with regular curcumin that is not standardised with regards to the curcuminoid proportions within the curcumin extract is therefore different from one curcumin 95% extract to another curcumin 95% extract. ANY OLD CURCUMIN IS SIMPLY NOT ANY OLD CURCUMIN!
It’s important to highlight that within the typical curcumin 95% extract three curcuminoids make up the 95% concentration. The problem is that from curcumin extract to extract these underlying curcuminoid proportions fluctuate and do so even for the same brand from batch to batch or lot to lot.

Our recent research, at Biologic Pharmamedical Research has been focussed on separating, isolating and mapping the pharmacology of these curcuminoid components in the context of multiple key proteins in this inflammatory pathway. Then to study each contribute in isolation to see how they modulate anti-inflammatory activity and other subcellular activities that help neutralise disease symptoms. The findings have led to game changing insight that puts a completely new perspective on curcumin and a new standard of drug design.

These curcuminoids can each have distinct pharmacological activity inside our cells targeting different proteins. One new one was discovered by Biologic Pharmamedical’s Franco Cavaleri PhDc. Even if you are certain you are buying a 95% extract every time, you do not have insight into how the underlying curcuminoid proportions have changed from your previous batch to alter the activity of your curcumin and your inflammation on the next purchase. Remember, the inflammatory pathway is comprised of a plethora of proteins that effect and regulate it from a 3 dimensional perspective. In addition keep in mind that NF-kB modulates as many as 150 genes!! This is complex and any minute shift produces monumental changes. In addition each protein is influenced, itself by a multitude of regulatory proteins any one of which could be defective in your specific disease state/pathology.

Our research at Biologic shows some of the newly discovered curcumioid activity to be synergistic to an intended therapeutic outcome. However, in other situations where the curcuminoid proportions shift the shifting can oppose an intended effect. Sometimes you get a potent 95 extract that works in your favour and other times you get a less effective one even though you think you have the same product.

The amazing knowledge to come out of this pharmaceutical research with these curcuminoids is a clearer understanding of the mechanism by which curcumin delivers its activity. In addition, we have found that nature has provided us with more intelligence within the curcumin extract that we are still working to extract. This latest ‘intelligence’ shows us an exponentially higher ORAC value that is measurably reliable: 125 x greater than regular curcumin. The key active curcuminoid fraction of this discovery is increased to 30% (ie BDM30) while regular curcumin only has 1% (ie BDM1) of this key active. Each curcuminoid portion is locked in for consistency and standardised to be reliable from lot to lot.

Moreover, it has allowed us to stabilise and create proportions of these underlying curcuminoids that serve our inflammatory targets with greater precision and make certain this activity is consistent from lot to lot.

Capture  BDM mod 30 III The result of this novel standard of curcumin pharmacology is BDM30™ -reliable curcuminoid composition standardisation; more effective measurement of activity; and consistent activity for curcumin that also exceeds 95% concentration! The patented Curcumin BDM30™ is the new household name used in the higher quality curcumin-based products. Look for products ‘made with BDM30’.

Conflict of Interest Statement. The author/researcher is the owner of a biomedical research group – Biologic Nutrigenomics Health Research Corp and Biologic Pharmamedical Research, that funds and executes research on the pharmacology of nutritional and nutraceutical agents that are studied in the context of disease pathology including characteristics that have been associated with inflammation and dementias. The research on these findings continues at clinical levels to further investigate the full indication-specific potential of this discovery. The author/researcher is also the owner of related Intellectual Properties. author copyright Franco Cavaleri PhDc

Franco Cavaleri, BSc, PhDc, is The Rhema Group’s Chief Science Officer. He is also the principal research scientist at Biologic Pharmamedical; is a former Mr. IFBB North America; and is completing a doctoral degree in Experimental Medicine in the Faculty of Medicine.

Franco Cavaleri Speaks to: The Impetus Behind the Curcumin Research and Medical Discoveries that Changes Everything

Ivan Leonov - Monday, November 20, 2017

The impetus behind the curcumin research and medical discoveries that changes everything we know about curcumin

As seen in the press release:

Initially driven by a passion to better understand nutraceuticals and nutrition in order to enhance performance during his quest to win the title of several North American bodybuilding competitions, Franco Cavaleri was struck with a serious autoimmune disease. This disease derailed Cavaleri twice with hospitilazation and with a prognosis of surgical intervention with prohibitive lifestyle consequences.
Although he struggled to stay healthy and stay on track with his academic and athletic careers, his struggles eventually led to desperation. In 1991 while preparing for the Mr. North America contest he was hospitalised for the first time in Vancouver’s St Paul’s Hospital. After having lost as much as fifty pounds his drug resistant condition was deemed untreatable.

After much introspection Franco speculated that a specialised curcuminoid extract he had been working in the lab with and using sporadically had taken the edge off his symptoms and allowed him to cope. It wasn’t until he had stopped the treatment that he was hospitalised. He decided to decline the surgical intervention and lean on his hypothesis. His rebound to optimal health led to the win in Redondo Beach, California in 1992 – Mr. IFBB North America.

After nearly 19 years of research and persistence with his unique treatment he decided to terminate the unique curcuminoid treatment that he speculated was no longer needed. Within months of running down his supply of his uniquely extracted curcuminoid compound, he was hospitalised again in 2009 with the same prognosis – drug resistant ulcerative colitis and surgery to resect the colon as the only alternative. This time his speculation about the efficacy of the treatment and its potential role turned to conviction and back he went to successfully treat and maintain long term remission with the unique extract that took several weeks to generate. This point in time generated the impetus that changed Cavaleri’s course of research forever. He made the decision to bring the strategy to formal medical drug research. Moreover, he committed to wed his 20 years of nutraceutical research to a formal initiative to study medicine and establish a medical PhD degree in experimental medicine using this natural medicine as the study subject matter of the thesis. His practical and academic experience and honed intuition in the field converged into a powerful outcome. The research was designed to determine the pharmacological mechanisms involved in this activity; and whether or not this biological activity played the role he believed it did in disease remission.

Cavaleri’s research into anti-inflammatory strategies originally used to support recovery from training, quickly became focused on better understanding the pharmacology of natural medicinal agents to rehabilitate his ulcerative colitis, without surgical intervention. Irrefutably, Cavaleri was able to overcome his disease without surgery!

According to Cavaleri, the key was to isolate an extract instrumental in reducing inflammation. Cavaleri achieved efficient separation of the curcuminoids within the regular curcumin extract more than 18 years ago and with the study of the pharmacology of each constituent independently in isolation, was eventually able to unravel the pharmacology of each constituent at a cellular and subcellular level in multiple cell lines and tissues. Over the decades his in-depth biomedical work mapped the pharmacology of these curcuminoids with regards to targeted subcellular proteins in an attempt to better understand why they worked to effect symptoms differentially. In this way, Cavaleri discovered a way to predict curcumin and curcuminoid activity and augment the curcuminoid proportions within the extract to manipulate the activity to be more target specific and reliable in terms of disease indication. The result is the new potential to design curcumin-based therapies with greater precision, with the ability to more selectively target subcellular proteins involved in development of disease symptoms and pathology, and increased efficacy by indication. These discoveries change everything we knew about curcumin setting in place a new industry standard and a new level of pharmacology for patients and consumers in need. Some of his work has been published. Some is still in peer review.

Cavaleri says there is still lots of work to do; to run more bench work and clinical research to determine more accurately how these natural medicines can be used to treat specific indications. Nevertheless, for now, they will cautiously use what has been discovered, patented and recently approved by the Canadian regulatory agency (NNHPD) while they continue the research at his medical laboratory, Biologic Pharmamedical Research (www.biologic-med.com).

 

Franco Cavaleri Speaks to: Curcumin BDM30 Supports Improved Recovery Rate From Training

Ivan Leonov - Thursday, November 16, 2017

Imagine being able to get into the gym to train a body part more frequently than your competition can. What does that mean to you in six months of steady training? Imagine recovering faster from a stage-to-stage or day-to-day workload in your competitive sport such as a cycling tour; a triathlon competition; or an all weekend cross-fit event. The advantage is possible with Curcumin BDM30™.

Research demonstrates that myogenic potential and anabolic drive can be limited by mismanaged NF-kB. NF-kB is a transcription factor responsible for regulating as many as 150 genes that manage and beckon the immune system and inflammatory response. Anabolic drive and recovery of lean muscle is meticulously orchestrated by the cytokines that NF-kB manages, including TNFα. TNFα partakes in and advances inflammation that is necessary but can also be a limiting factor in your pursuit to maximum form.

The inflammatory process plays an important role in recovery and regeneration of tissue, including myogenesis (muscle generation). Skeletal muscle cells are said to be one of the most adaptable cells/tissue of the body. The underlying objective with resistance training, for example, is to evoke microtrauma of the working skeletal muscle cells resulting in cell signalling that activates satellite cells in the vicinity of the strained fiber. This activation prompts aggregation and fusing of these cells with mature muscle fibers. This is ultimately the compensatory hypertrophy we expect to occur as an adaptation feature to the extra-ordinary workload, adding muscle mass and strength over time.

That prolonged soreness that often persists to the next training day, however, is a problem. Prolonged survival of that post-workout soreness is indicative of longstanding TNFα and inflammation; and interference with maximum recovery potential. That means interference with your own human potential.

Research shows TNFα also inhibits myogenesis the mechanism of which is repression of MyoD protein. MyoD expression is central to cell restoration and differentiation – it’s essential to the zzzsprinterx generation of muscle tissue. Prolonged survival of the inflammatory process to inhibit MyoD protein interferes with recovery, immunity and myogenic (muscle building) potential. Downregulation of training-related and age-related inflammatory activity has both an anticatabolic influence and promotes anabolic drive to restore maximum muscle protein anabolism.

Although curcumin can deliver an inhibitory effect on NF-kB transactivation and transcription of inflammatory cytokines, including TNFα, the new discoveries showing MSK1 inhibition by BDMC (Curcumin III) changes the game. Curcumin BDM30™ is a result of these discoveries and it stops inflammation at a subcellular level where inflammatory proteins are generated. Investing the time and effort into training to improve health and squating guy advance performance requires the best return possible. Imagine again being able to get into the gym to train a body part or work a training cycle more frequently than your competition can. Imagine again, maximising MyoD expression and anabolic drive. This time get with the program to make it happen with Curcumin BDM30™ taken daily just before or after the workout. If you don’t, someone you know will likely beat you to it and may even do so to the first place podium.


Franco Cavaleri, BSc, PhDc, is The Rhema Group’s Chief Science Officer. He is the principal research scientist at Biologic Pharmamedical. Franco Cavaleri is also a former IFBB Mr. North America having practiced the science.

Conflict of Interest Statement. The author/researcher is the owner of a biomedical research group – Biologic Nutrigenomics Health Research Corp and Biologic Pharmamedical Research, that funds and executes research on the pharmacology of nutritional and nutraceutical agents that are studied in the context of disease pathology including characteristics that have been associated with inflammation and dementias. The research on these findings continues at clinical levels to further investigate the full indication-specific potential of this discovery. The author/researcher is also the owner of related Intellectual Properties. author copyright Franco Cavaleri PhDc

Franco Cavaleri Speaks to: Glucose vs Ketones vs KETOBA for cellular energy

Ivan Leonov - Wednesday, November 15, 2017

 

Supplementation with exogenous ketones is skyrocketing to new levels. Nevertheless, the information about these supplements is getting more and more confusing with regulatory agencies trying to catch up to the messaging. KETOBA™ is designed based on the patent particulars owned by Biologic Nutrigenomics and the only exogenous ketone product currently approved by the CFIA’s Natural Health Product Directorate with an assigned NPN number approving its sales and safe use. KETOBA™ is not a typical exogenous ketone. It is much more.

KETOBA™ is an activated ketone; activated by the accompaniment of the beta-hydroxybutyrate (ketone body) by butyric acid. Butyric acid, a short chain fatty acid, is an activator of β-oxidation to stimulate ketogenesis. It does not induce the same gastrointestinal distress risks that medium chain triglycerides pose. Butyric acid supports glucose clearance to reduce competition by glucose in serum while facilitating ketone generation (ketogenesis) by the liver. These pharmacological characteristics form the basis of the ‘activated ketone’ description. Butyric acid also plays a central role in gastrointestinal health supporting an environment that voids pathogens and nurtures friendly gut bacteria.

The boiled down distinct difference between KETOBA™ and the typical ketone is very simply rendered down to KETOSIS versus KETOGENESIS. Butyric acid, the short chain fatty acid is the key! The Ketone will induce ketosis to increase serum ketones from an exogenous source. Nevertheless, one needs to burn through these calories before ‘burning’ endogenous fat calories for energy. KETOBA™ is primarily designed to INDUCE KETOGENESIS to get the body to generate ketones from endogenous fat sources; to help you utilise serum fat as an energy source. Best taken on an empty stomach before a fasting workout. Do not use if mental and body energy are not desired.

Conflict of Interest Statement. The author/researcher is the owner of a biomedical research group – Biologic Nutrigenomics Health Research Corp and Biologic Pharmamedical Research, that funds and executes research on the pharmacology of nutritional and nutraceutical agents that are studied in the context of disease pathology including characteristics that have been associated with inflammation and dementias. The author/researcher is also the owner of related Intellectual Properties. author copyright Franco Cavaleri PhDc

Franco Cavaleri, BSc, PhDc, is The Rhema Group’s Chief Science Officer. He is also the principal research scientist at Biologic Pharmamedical; is a former Mr. IFBB North America; and is completing a doctoral degree in Experimental Medicine in the Faculty of Medicine.


 

Franco Cavaleri Speaks to: The Challenges Around Ketosis

Ivan Leonov - Wednesday, November 15, 2017

Franco Cavaleri, BSc, PhDc Experimental Medicine; Mr. IFBB North America

If you think you’re in ketosis because you’ve decided to will and grunt your way through a carb-limited diet, think again. It’s not that easy even if you sacrificed day in and day out.
Glucogenic amino acids, those that can be converted to glucose, such as alanine, glycine and cysteine are prevalent in most protein sources we consider to be high biological value (BV). High BV protein sources are those typically associated with high anabolic support and maximum tissue nitrogen retention and regeneration, including whey, beef, egg, pork, fish and turkey. Reducing protein intake and elevating dietary fat intake is a common solution that supports a low-carb intake if ketosis is the goal. It can work.

However, if your goal is maximum power and muscle as an athlete, the question you must ask: Is it an effective option to eliminate high BV protein from your diet and still maintain, let alone, build lean muscle amid intensive training? This is good question that has not been convincingly answered. My opinion based on data interpretation and long intense personal experience in the bodybuilding arena is an emphatic NO!

Escalating dietary fat intake with the right sources is certainly a viable option, as long as the carbohydrate intake is limited at the same time. This facilitates ketosis and spares protein for anabolism. It may be enough for sedentary folks; but it won’t be enough if you are lifting heavy or pushing your body to other physical extremes.

Nevertheless, monitoring one’s macronutrient intake to meet daily demands, which can range considerably for each individual based on genetic variance, sleep, stress, exercise changes/intensity, nutrient density, and meal frequency, is a monumental task that usually fails due to lack of knowledge and experience. For those looking to achieve a ketogenic state, staying in the zone and in full cognitive and physical function is a daunting task often riddled by downturns in energy substrate availability.

If you are training hard to build muscle or in extensive endurance programs, glycogen restoration is a MUST as a post-workout endeavour. If you don’t glycogen restore and maintain daily requisite protein, then expect to perform short of maximum. I’ve been there and can tell you with absolute certainty if you are not fully glycogen loaded you can’t perform even if you’re only lifting singles for a maximum bench or squat. I’ve squatted in excess of 7 x 45 lb plates on each side of a bowing bar (>710 lbs) glycogen depleted I wouldn’t even be able to get that bar off the rack, let alone perform the squat. That full muscle belly generates significant turgor pressure from within on a lift that produces physical support from head to toe and this means not just energetic support. If maximum lean muscle and power is the goal, protein intake will be needed far beyond that allowed by the strict ketogenic program; … and as for carb intake… you have to find a way to maintain muscle glycogen in countering proportion to your usage.

Conflict of Interest Statement. The author/researcher is the owner of a biomedical research group – Biologic Nutrigenomics Health Research Corp and Biologic Pharmamedical Research, that funds and executes research on the pharmacology of nutritional and nutraceutical agents that are studied in the context of disease pathology including characteristics that have been associated with inflammation and dementias. The author/researcher is also the owner of related Intellectual Properties. author copyright Franco Cavaleri PhDc

Franco Cavaleri, BSc, PhDc, is The Rhema Group’s Chief Science Officer. He is also the principal research scientist at Biologic Pharmamedical; is a former Mr. IFBB North America; and is completing a doctoral degree in Experimental Medicine in the Faculty of Medicine.


Franco Cavaleri Speaks to: Exploring the Ketogenic Diet

Ivan Leonov - Wednesday, November 15, 2017

 

Ketogenic diets have become the big buzz today and for good reason! The ultra low-carb, high-fat diet can help with weight loss and improved health. By vastly reducing carbohydrates in your diet, your body is put into a metabolic state called ketosis (if all the other macros fall in place), which results in it becoming more efficient at burning fat for energy. Nevertheless, the benefits far exceed fat meltdown.

The ketogenic diet has taken many forms, from those that merely eliminate high glycemic index carbs, but still incorporate low glycemic alternatives to those that avoid carbohydrate sources from the diet altogether (or as close to zero as possible). Nevertheless, in order for the ketogenic objective to prevail and ketosis to manifest the daily carb intake must be as low as 50 grams or less. If you decide to significantly limit carbohydrate sources from your diet, your cells will require an alternative energy source.

The body is very efficient at ensuring survival and generating glucose from alternative nutrients, including protein, if you choose to drag yourself through a carb-restricted program. Dietary carbohydrate sources serve to spare dietary protein; therefore, on the ketogenic diet where carb intake is limited the precious protein supply can be sacrificed in order to generate glucose and diverted from cell, fluid, hormone and tissue regeneration and maintenance. Although protein catabolism can be limited by increasing dietary fat intake protein intake still needs to be limited if optimal ketosis is desired So for builders and power athletes depending on optimal lean body mass a strict ketogenic diet may not serve the objective maximally.

In such cases following the low carb/high fat (LCHF) feature of the ketogenic diet that is modified to heighten protein intake, however, can play a positive role and produce a positive outcome for athletes relying on a myogenic or muscle building outcome. The million dollar question that we’ll get to see variable answers to in the coming article series is: Does this protein augmentation really support true metabolic ketosis?

The ketogenic diet is not for everyone, as it can be very restrictive and difficult to maintain. In fact, medical ketogenic applications are typically only employed as therapeutic programs, and can work effectively for insulin support and ultimately serum glucose regulation, as well as in support of cognition in cases of neurological deficits associated with dementia. It also has a long history as an effective treatment for drug-resistant epilepsy.

In fact, ketosis can play a monumental role in the treatment of these disorders and for reasons that extend beyond the voidance of serum glucose. The ketone bodies generated by the ketogenic macronutrient profile, themselves serve as cell signalling agents in ways similar to how keys turn on or turn off engines; or buttons control light switches. Ketones are powerful ligands for receptors that set in motion a plethora of metabolic changes that appear to favour healthy outcomes.

The challenge that ketogenic initiatives posed in the past don’t have to be a challenge at all today while the benefits are pursued. There are effective strategies that can be applied to facilitate ketosis and support the metabolism, mind and body through the transition from one energy substrate (glucose) as the primary to the ketone without that mental drag and lag associated with dietary carb restriction.

Conflict of Interest Statement. The author/researcher is the owner of a biomedical research group – Biologic Nutrigenomics Health Research Corp and Biologic Pharmamedical Research, that funds and executes research on the pharmacology of nutritional and nutraceutical agents that are studied in the context of disease pathology including characteristics that have been associated with inflammation and dementias. The author/researcher is also the owner of related Intellectual Properties. author copyright Franco Cavaleri PhDc

Franco Cavaleri, BSc, PhDc, is The Rhema Group’s Chief Science Officer. He is also the principal research scientist at Biologic Pharmamedical; is a former Mr. IFBB North America; and is completing a doctoral degree in Experimental Medicine in the Faculty of Medicine.


 

Franco Cavaleri Speaks to: Your Metabolism on Ketoba

Ivan Leonov - Wednesday, November 15, 2017

 

The best builders’ dietary program must keep dietary protein at a level that serves anabolism (building new tissue), which means consuming higher amounts of protein than the strict medical ketogenic diet allows for. Adding the exogenous ketones helps preserve protein for anabolism and prevent lean tissue catabolism (breaking down complex molecules and releasing energy). Using KETOBA twice per day maintains a buffer zone of serum ketones despite dietary choices. This allows for incremental protein intake to meet higher demands created by intense exercise while maintaining functional serum ketone levels that would otherwise be reduced by the introduction of a glucogenic (contributing to glucose production) protein source.

One step further: adding short-chain fatty acids (SCFA) like butyrate/butyric acid (BA) with the ketone body, like β-hydroxybutyrate zzzschematic(BHB), synergises the exogenous ketone serving as a β-oxidation trigger. BA supports the effects of the exogenous ketone by contributing to serum levels from endogenous sources and does so without gastrointestinal (GI) distress. This distress is commonly associated with high dose oral ketone and/or Medium Chain Triglyceride (MCT), and counters performance and immunity by disrupting probiotic stability and interfering with resorption of electrolytes and water.

Dehydration and electrolyte depletion are an athlete’s worst nightmare, compromising muscle mass strength and endurance. GI distress impairs exercise performance, and doesn’t support optimal health and immunity either. BA is a SCFA that facilitates electrolyte and water reabsorption and helps balance probiotic culture in the colon. Colonocytes, epithelial cells in the colon, use BA as an energy source and a down-regulator of inflammation. In addition BA delivers a pharmacology that supports insulin efficiency and blood sugar management, allowing the ketone (BHB) an opportunity to surface in serum as a primary energy (ATP) substrate. BA also supports cognitive performance and cardiovascular health.

The name KETOBA is formed from ketone (BHB) coupled with BA, the short-chain fatty acid. Hence KETO-BA.

Conflict of Interest Statement. The author/researcher is the owner of a biomedical research group – Biologic Nutrigenomics Health Research Corp and Biologic Pharmamedical Research, that funds and executes research on the pharmacology of nutritional and nutraceutical agents that are studied in the context of disease pathology including characteristics that have been associated with inflammation and dementias. The author/researcher is also the owner of related Intellectual Properties. author copyright Franco Cavaleri PhDc

Franco Cavaleri, BSc, PhDc, is The Rhema Group’s Chief Science Officer. He is also the principal research scientist at Biologic Pharmamedical; is a former Mr. IFBB North America; and is completing a doctoral degree in Experimental Medicine in the Faculty of Medicine.


 

Franco Cavaleri Speaks to: Curcumin III Makes Curcumin BDM30 the New Standard

Ivan Leonov - Wednesday, November 15, 2017

 

Curcumin BDM30™ is not regular curcumin. Curcumin BDM30™ is based on a recent research discovery that changes what we know about curcumin and how we can use it to deliver therapeutic relief. The discovery made at Biologic Pharmamamedical Research by Franco Cavaleri PhDc has recently been granted full patent status after a lengthy review; and NPN status for approved sales/safety and validation of researched claims. How is it different? Curcumin is typically comprised of three main curcuminoids. Every curcumin extract product supplies all three curcuminoids in a ratio similar to: curcumin I (70-80%); curcumin II (12-20%); curcumin III (0.5-1.5%). The latest discovery made by Franco Cavaleri, PhDc, the principal research scientist at Biologic Pharmamedical (www.biologic-med.com), and the Chief Science Officer at Rhema Health Products, shows for the first time that curcumin III and not curcumins I or II inhibits (helps control) MSK1.

MSK1 is a regulatory protein that regulates production (transactivation) of inflammatory chemicals at a genomic level. leg kneeBy turning this MSK1 level down the, cells – the body – are better able to control inflammation from a second pathway that is additive to the one regular basic curcumin helps control. Curcumin III does everything the other curcuminoids do plus it helps regulate MSK1 for incremental anti-inflammatory support from a second control point.

This same research shows that regular curcumin extract (even the 95%) does not affect MSK1 in any positive way. Curcumin III levels are simply not high enough for functionality in regular curcumin. The new Curcumin BDM30™ is a new standard of anti-inflammatory offering 60x more BDMC (curcumin III) than regular curcumin, providing immense joint pain relief and more rapid recovery from inflammation caused from injuries and exercise.

Conflict of Interest Statement. The author/researcher is the owner of a biomedical research group – Biologic Nutrigenomics Health Research Corp and Biologic Pharmamedical Research, that funds and executes research on the pharmacology of nutritional and nutraceutical agents that are studied in the context of disease pathology including characteristics that have been associated with inflammation and dementias. The author/researcher is also the owner of related Intellectual Properties. author copyright Franco Cavaleri PhDc.

Franco Cavaleri, BSc, PhDc, is The Rhema Group’s Chief Science Officer. He is also the principal research scientist at Biologic Pharmamedical; is a former Mr. IFBB North America; and is completing a doctoral degree in Experimental Medicine in the Faculty of Medicine.


 

Franco Cavaleri Speaks to: Ketogenic Diets - How Ketosis Factors Into Atkins

Ivan Leonov - Wednesday, November 15, 2017

As we’ve all seen, diets come and go and come again. Most fat-loss strategies deliver horrific consequences, but amazingly they’re kept alive by people desperately seeking magical solutions. Most diets result in weight loss because they lack calories but also deplete the body of glycogen, water, and muscle. You probably know many of these nutrient-deficient prescriptions for disaster: the grapefruit-and-water diet; the banana-and-water diet; the crème-and-protein-diet; the high-carbohydrate, low-to-no-fat diet; the liquids-only diet; the one-meal-per-day diet; the fruit-only diet; the lemon/ water fasting; the high-protein, high-fat diet; the no-carbohydrate diet.

One diet that really scares me, though, is the high-protein, high-fat, no-carbohydrate one popularized by the late Dr. Robert C. Atkins, which has been widely marketed and media-hyped. To my astonishment, this outlandish program has been universally accepted as safe. The Atkins Diet involves the consumption of as much protein from red-meat sources with as much animal fat as desired. I’m a proponent of abundant dietary fat, but not just any old fat. As we’ve seen, there are some fats we need to avoid and others we should consume abundantly.

The Atkins Diet is ketogenic. Few people know what they’re actually doing to their biochemistry by struggling through such a regimen. Within the liver two molecules of acetyl coenzyme A (acetyl CoA) are combined to yield ketone bodies—acetoacetic acid, beta-hydroxybutyric acid, and acetone, which are ultimately produced as a result of ketogenesis. Acetyl CoA can be obtained from dietary fats, dietary protein, or body tissues.

When dietary carbohydrates are depleted, the body quickly uses up its stored glycogen levels. Athletes or those in pursuit of quick weight loss learn to use ketone sticks (which measure ketone body levels in urine) to determine whether ketosis (the abnormal increase of ketone bodies in the body) has been induced by a low- to zero-carbohydrate diet.

Once the ketogenic state is reached, however, most of these athletes know to back away from the carbohydrate restriction and increase dietary carbohydrates to a level that prevents muscle catabolism and ketosis from persisting. It takes about 50 to 70 g (one potato, two apples, or two bananas) of carbohydrates daily to prevent ketosis for the average person. The popular ketogenic Atkins Diet involves the indiscriminate consumption of deep-fried and pan-fried globs of animal fat. This high-fat, high-protein, low- or no-carbohydrate program promotes the production of ketone bodies. Cells in muscles and other tissues have the ability to employ these substances as a source of energy.

When dietary carbohydrates are severely limited, ketone bodies can be produced in greater quantities than the body can use for energy. The Atkins Diet involves severe carbohydrate limitation. When dietary protein and fat are too high, ketone bodies can’t be oxidized in the body fast enough to remove the potential danger they pose. The body expels excessive ketone bodies in the urine and through the lungs. In fact, you can often smell acetone on the breath of an individual who’s been in ketosis for some time. Ketone bodies can also be detected on the breath of a diabetic when he or she fails to metabolize carbohydrates efficiently due to inefficient or insufficient insulin secretions.

The Atkins Diet promotes the abundant consumption of beef and dairy fats, which contain a great deal of arachidonic acid. Overconsumption of these arachidonic-acid-laden sources multiplies the risk of biochemical imbalances that are at the root of a multitude of epidemics, including obesity. That’s especially so when a diet such as the Atkins one is devoid of vegetables, whole grains, and legumes that would otherwise supply antioxidants, vitamins, and fuel for a starving body and friendly intestinal bacteria. The change in colon pH that this diet encourages is a perfect environment for pathogenic bacteria to disrupt friendly bacterial health, increasing the danger of colon cancer (24, 25). Not only does the lack of fiber in this diet contribute to the incidence of colon cancer, the high degree of dietary saturated fat does, as well. The indiscriminate fat consumption advocated by the Atkins Diet can also facilitate cardiovascular problems and interrupt insulin function. Furthermore, abundant red-meat consumption can cause colon cancer through factors independent of fat content (26).

With a nearzero intake of dietary carbohydrates, this diet creates a temporary depletion of hepatic glycogen. Glycogen is the liver’s main fuel for detoxification and metabolic activity. Exhaust this energy source and you’re in trouble.

The ketogenic state induced by the Atkins Diet and others like it alters the pH (acid/base balance) of the blood and body to induce more metabolic havoc (27, 28). The body functions in a pH range that’s quite narrow. Mild deviations result in profound metabolic impairment. Interestingly the ketogenic diet doesn’t change the pH of the brain. Carbohydrate-restricted diets like the one expounded by Dr. Atkins have been in use since the 1920s to help treat epileptic children with great success (29, 30, 31). The ketogenic diet somehow reduces seizure activity, but scientists still don’t know why. And ketogenic diets have been shown through some unknown mechanism to boost brain ATP, as well (32). However, a ketogenic diet must be carefully monitored in these therapeutic applications to help manage the potential acidosis of the body. As the body fights to maintain its functional acid-alkaline balance, nutrient stores, such as calcium and phosphorus from bone mass, might be taxed. Furthermore, cases of renal stone development, gastritis, ulcerative colitis, alteration of mentation, and hyperlipidemia have been reported with the administration of a ketogenic diet. Of course, with professional monitoring the risk of these side effects can be minimized (33). The dangers might be a good trade-off when considering the implications of an uncontrollable epileptic condition, especially when it’s severe. Still, for basic weight management a ketogenic diet isn’t advisable. The risks aren’t lower than those posed by excess body fat.

If an epileptic condition presents significant danger in your life, sure, the ketogenic diet is likely a reasonable choice, but I still believe that ketogenesis might not have anything to do, or at least all to do, with the beneficial effect of the typical ketogenic diet on an epileptic condition. Keep in mind that the biochemical process by which ketogenesis seems to eliminate or reduce seizure activity isn’t known. Many studies demonstrate that polyunsaturated fatty-acid supplementation with linoleic and alpha linolenic acid, as well as with the fish-oil-derived DHA and EPA, also promotes brain health and inhibits epileptic seizures (34, 35, 36, 37, 38). The typical ketogenic diet involves greater intakes of fats, primarily animal ones, that have high essential-fat content as well as healthy EPA and DHA levels. It also entails the consumption of a lot of vegetable oils that consist of a bounty of linoleic and alpha linolenic acids.

Could it be that the method of therapeutic activity for the anti-epileptic ketogenic diet is simply through its rich supply of the essential and other health-promoting polyunsaturated, omega-3 fats that in the absence of dietary carbohydrates and reduced insulin activity leaves more fats for the brain to take up? Likely so. It’s at least one major contributing factor. I’m confident that the high polyunsaturated-fat version of Ageless Performance will prove to be a significant therapy for epileptic seizures the way ketogenic diets have but without the side effects and with a broader array of health benefits. Studies may ensue in the near future.

In addition to increased cardiovascular risk from the abundant dietary saturated fat, the dearth of vegetation and whole grains in the ketogenic Atkins-type diet results in a lack of the vitamin co-factors required to metabolize homocysteine. The accumulation of homocysteine occurs due to inefficient methionine metabolism. Red meats are rich in methionine. Eat them lavishly with few or no vegetables and you’ll likely run into trouble. A shortage of vitamins B6 and B12, folic acid, and methyldonors (such as SAMe and trimethylglycine) can increase the incidence of homocysteine-related problems. Homocysteine buildup has been implicated in cardiovascular disease, cerebrovascular problems, inflammation, chronic fatigue, and cognitive and other brain disorders. The Atkins Diet can create a predisposition for these common risks with the silent killer, cardiovascular disease, creeping up to get you without previous warning.

Although Ageless Performance focuses on limiting dietary carbohydrates, the objective is far from elimination. As part of the program, low-glycemicindex carbohydrates are consumed abundantly to fuel the brain and body without imposing an extreme insulinogenic influence, and ketogenesis doesn’t enter the picture. In the stressed ketogenic state, weight reduction can be significant (as much as 10 to 15 pounds in a week or two); however, most of the weight lost in the first phase of the Atkins Diet is water, glycogen, and muscle, not fat (39).

Although the Atkins Diet weight loss is attributed to the depletion of the body’s carbohydrate (glycogen) stores, most people are fooled into thinking this is a healthy outcome. Earlier I explained the carbohydratedepletion tricks for making weight classes at bodybuilding shows. Low or zero carbohydrate diets cause glycogen to be lost in the body rapidly. This also causes water to leave the body very quickly.

The result is significant:

Immediate weight loss might exceed 10 pounds, though fat won’t necessarily be reduced. Wrestlers use the same techniques to make weight classes, and a 1993 review in the International Journal of Sports Medicine indicates that the weight losses in these cases aren’t necessarily fat, either; worse, the metabolic impairment these practices induce can make fat loss even harder to achieve in future attempts (40).

Conflict of Interest Statement. The author/researcher is the owner of a biomedical research group – Biologic Nutrigenomics Health Research Corp and Biologic Pharmamedical Research, that funds and executes research on the pharmacology of nutritional and nutraceutical agents that are studied in the context of disease pathology including characteristics that have been associated with inflammation and dementias. The author/researcher is also the owner of related Intellectual Properties. author copyright Franco Cavaleri PhDc
Franco Cavaleri, BSc, PhDc, is The Rhema Group’s Chief Science Officer. He is also the principal research scientist at Biologic Pharmamedical; is a former Mr. IFBB North America; and is completing a doctoral degree in Experimental Medicine in the Faculty of Medicine.


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