The same research showing curcumin III inhibits MSK1 in the inflammatory process shows that the common curcumin extract (95% or other) as well as curcumins
I and II do not stop or inhibit the protein. Curcumin III levels are simply not high enough for functionality in regular curcumin. The new Curcumin
BDM30™ is a new standard of anti-inflammatory offering 60x more BDMC (curcumin III) than regular curcumin, providing joint pain relief and more
rapid recovery from inflammation caused from injuries and exercise.
The inflammatory process plays an important role in recovery and regeneration of tissue, including myogenesis (muscle generation). Skeletal muscle cells
are said to be one of the most adaptable cells/tissue of the body. The underlying objective with resistance training, for example, is to evoke microtrauma
of the working skeletal muscle cells resulting in cell signalling that activates satellite cells in the vicinity of the strained fiber. This activation
prompts aggregation and fusing of these cells with mature muscle fibers. This is ultimately the compensatory hypertrophy we expect to occur as an adaptation
feature to the extra-ordinary workload, adding muscle mass and strength over time.
That prolonged soreness that often persists to the next training day, however, is a problem. Prolonged survival of that post-workout soreness is indicative
of longstanding TNFα and inflammation; and interference with maximum recovery potential.
That means interference with your own human potential. BDM30™ inhibits prolonged survival of TNFα and prolonged inflammation (including soreness). This supports maximal recovery and regeneration.
Curcumin BDM30™ exhibits a profound antioxidant potential never seen before on the planet jumping the ORAC value to an unprecedented 1,130,000 mM/TE per 600 mg Curcumin BDM30™ (125X more than regular curcumin). To put this in perspective, regular curcumin 95% delivers an ORAC value of 9000 mM/TE per 600 mg.
Adding to the abovementioned outstanding outside-in antioxidant activity, curcumin III (BDMC) is shown to activate endogenous or internal antioxidants that protect organelles of the cell by inducing Nrf2 activity. The Curcumin BDM30™ activity on Nrf2 delivers its inside-out protection of DNA, mitochondria, membranes and other intracellular life essentials by improving antioxidant status (like glutathione) inside the cell.
Anti-inflammatory relief and recovery is experienced faster with BDM30™ upon administration
As little as a few hours instead of days
Less curcumin is required to deliver results when using BDM30™
BDM30™ will provide more relief for difficult inflammatory conditions
Curcumin BDM30™ is designed to help manage inflammation, joint pain and discomfort, and support recovery from day-to-day workouts or injuries. Over
and above the new standard of anti-inflammatory activity this recent discovery presents a dual phase antioxidant defense program: antioxidant protection
from the outside –in and antioxidant protection from the inside-out.
MSK1 is a regulatory protein that regulates production (transactivation) of inflammatory chemicals at a genomic level. By turning this MSK1 level down the cells – the body - are better able to control inflammation from a second pathway that is additive to the one regular basic curcumin helps control. Curcumin III does everything the other curcuminoids do plus it helps regulate MSK1 for incremental anti-inflammatory support from a second control point.
Nrf2 is a regulator of the endogenous antioxidant defense systems built into our cells - Catalase (CAT), Super Oxide Dismutase (SOD), Glutathione peroxidase
enzymes (GPx) and others. The widespread existence of Nrf2 and its role in cellular protection as a master regulator of antioxidant defense makes it
a viable target for upregulation against toxicity in most organs and tissues of the body.
Nrf2 induction or overexpression is shown to heighten cellular defense mechanisms during metabolic stress and convey neuroprotection during toxin-induced stress to the point of reduced lesion development. This cellular protection is also seen in the context of chemotherapy where concurrent Nrf2 induction protects healthy cells. Nrf2 induction is shown to convey critical defense against elevated serum-glucose-induced oxidative injury to cardiac muscle cells.
Contains 30% bisdemethoxycurcumin (BDMC); regular curcumin extract contains 1%
BDMC improves curcumin stability, bioavailability and survival in blood
BDMC offers an ORAC of 6,245,000 UNITS; regular curcumin’s ORAC is 9,500 UNITS
BDMC inhibits NF-kB and MSK1 to combat inflammation from two targets; regular curcumin only inhibits NF-kB
BDM30™ and BDM50™ are already bioavailability-enhanced. Bioperin, for example, has certainly been used for the longest time as an enhancer
of bioavailability and serum survival for various botanicals. Nevertheless, the studies of such can be significantly manipulated to produce favourable
outcomes so in real practice this activity is hit and miss. Having said that, the way BDM30™ and BDM50™ are designed the curcumin III (
bisdemethoxycurcumin) fraction is significantly increased from 1% naturally to as much as 50% in BDM technology and this provides improved stability
for the other curcuminoids. Research also shows it facilitates bioavailability of the entire group of curcuminoids. Curcumin III acts in a lot of ways
like bioperin has been shown to interact biologically: to alter p450 enzyme activity in support of better curcuminoid serum survival. However, over
and above this pharmacology, curcumin III helps protect and preserve curcuminoid stability in solution as well.
Curcumin III delivers an ORAC (Oxygen Radical Absorbance Capacity) value that outperforms any compound we’ve studied in the past. It is in the order of 6,245,000 UNITS. As an example, to gain perspective, regular curcumin exhibits an ORAC value of only 9,500 UNITS when measured in precisely the same manner. This activity plays a huge role in stability preservation of the curcumin pharmacology and more; including the newly discovered additive anti-inflammatory pharmacology curcumin III delivers. Curcumin III’s properties override the benefits Bioperin offers as an added ingredient and allows us to deliver full curcuminoid load in the capsule by simply utilising curcumin’s inherent activity without compromising curcumin concentration. This is why reports from users reliably indicate faster results (within hours instead of days) and more intense anti-inflammatory (relief) activity with the BDM30™ /50 technologies.